产品名称 | FGFR1 Fibroblast Growth Factor Receptor 1 Fc Chimera Human Recombinant Protein |
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产品描述 | Soluble FGFR-1a (IIIc) Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric, glycosylated, Polypeptide chain and having a molecular mass of 170 kDa. The FGFR1 is purified by proprietary chromatographic techniques. |
文献引用格式 | FGFR1 Fibroblast Growth Factor Receptor 1 Fc Chimera Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTP11362) |
应用范围 | Cell Culture |
抗体来源 | No |
产品形态 | Sterile Filtered White lyophilized (freeze-dried) powder. |
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内容 | CD331 was lyophilized from a concentrated (1 mg/ml) sterile solution containing 1xPBS. *可以提供无载体抗体。 |
储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
基因名 | FGFR1 |
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基因全名 | Fibroblast growth factor receptor 1 |
蛋白功能 | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. |
Tissue Specificity | Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. |
Uniprot ID | FGFR1: P11362 |
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