FEN1 Flap Structure-Specific Endonuclease 1 Human Recombinant Protein 1mg

产品概况

产品名称	FEN1 Flap Structure-Specific Endonuclease 1 Human Recombinant Protein
产品描述	FEN1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 380 amino acids (1-380 a.a.) and having a molecular mass of 42.5 kDa. The FEN1 protein is purified by standard chromatogrpahy techniques.
文献引用格式	FEN1 Flap Structure-Specific Endonuclease 1 Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTP39748)
应用范围	Cell Culture
抗体来源	No

产品名称

FEN1 Flap Structure-Specific Endonuclease 1 Human Recombinant Protein

产品描述

FEN1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 380 amino acids (1-380 a.a.) and having a molecular mass of 42.5 kDa. The FEN1 protein is purified by standard chromatogrpahy techniques.

文献引用格式

FEN1 Flap Structure-Specific Endonuclease 1 Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTP39748)

应用范围

Cell Culture

抗体来源

产品详情

产品形态	Sterile filtered colorless solution.
内容	The protein contains 20mM Tris-HCl buffer pH-8.0, 1mM DTT, 10% glycerol. *可以提供无载体抗体。
储存条件	Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles.

产品形态

Sterile filtered colorless solution.

内容

The protein contains 20mM Tris-HCl buffer pH-8.0, 1mM DTT, 10% glycerol.
*可以提供无载体抗体。

储存条件

Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles.

指标相关信息 (来源: Uniprot.org)

基因名	FEN1
基因全名	Flap endonuclease 1
蛋白功能	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Uniprot ID	FEN1: P39748

基因名

FEN1

基因全名

Flap endonuclease 1

蛋白功能

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

Uniprot ID

FEN1: P39748

实验耗材

分子生物学试剂

蛋白与免疫学

生化试剂

细胞及检测试剂

色谱及层析

仪器设备

实验服务

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