产品名称 | CCNH Cyclin-H Human Recombinant Protein |
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产品描述 | CCNH Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 343 amino acids (1-323 a.a.) and having a molecular mass of 39.8 kDa. The CCNH is fused to a 20 amino acid His Tag and purified by proprietary chromatographic techniques. |
文献引用格式 | CCNH Cyclin-H Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTP51946) |
应用范围 | Cell Culture |
抗体来源 | No |
产品形态 | Sterile Filtered clear colorless solution. |
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内容 | The CCNH solution contains 20mM Tris-HCl pH-8, 2mM DTT, 2mM EDTA, 0.1M NaCl and 30% glycerol. *可以提供无载体抗体。 |
储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
基因名 | CCNH |
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基因全名 | Cyclin-H |
蛋白功能 | Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. |
Uniprot ID | CCNH: P51946 |
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