CAMK4 Calcium/Calmodulin-Dependent Protein Kinase IV Human Recombinant Protein 1mg

产品概况

产品名称	CAMK4 Calcium/Calmodulin-Dependent Protein Kinase IV Human Recombinant Protein
产品描述	CAMK4 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 497 amino acids (1-473) and having a molecular mass of 54.5kDa. CAMK4 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
文献引用格式	CAMK4 Calcium/Calmodulin-Dependent Protein Kinase IV Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTQ16566)
应用范围	Cell Culture
抗体来源	No

产品名称

CAMK4 Calcium/Calmodulin-Dependent Protein Kinase IV Human Recombinant Protein

产品描述

CAMK4 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 497 amino acids (1-473) and having a molecular mass of 54.5kDa.
CAMK4 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

文献引用格式

CAMK4 Calcium/Calmodulin-Dependent Protein Kinase IV Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTQ16566)

应用范围

Cell Culture

抗体来源

产品详情

产品形态	Sterile Filtered colorless solution.
内容	The CAMK4 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl and 10% glycerol. *可以提供无载体抗体。
储存条件	Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles.

产品形态

Sterile Filtered colorless solution.

内容

The CAMK4 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl and 10% glycerol.
*可以提供无载体抗体。

储存条件

Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles.

指标相关信息 (来源: Uniprot.org)

基因名	CAMK4
基因全名	Calcium/calmodulin-dependent protein kinase type IV
蛋白功能	Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
Tissue Specificity	Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.
Uniprot ID	CAMK4: Q16566

基因名

CAMK4

基因全名

Calcium/calmodulin-dependent protein kinase type IV

蛋白功能

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

Tissue Specificity

Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.

Uniprot ID

CAMK4: Q16566

实验耗材

分子生物学试剂

蛋白与免疫学

生化试剂

细胞及检测试剂

色谱及层析

仪器设备

实验服务

办公用品