产品名称 | ADAM10 A Disintegrin and Metalloproteinase Domain 10 Human Recombinant Protein |
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产品描述 | ADAM10 extracellular domain minus the signal peptide and pro-sequence Human Recombinant fused to N-terminal His-Tag produced in E.Coli is a single, non-glycosylated polypeptide chain containing 459 amino acids (214-672) and having a molecular mass of 55.089kDa. |
文献引用格式 | ADAM10 A Disintegrin and Metalloproteinase Domain 10 Human Recombinant Protein (Boster Biological Technology, Wuhan, China. Catalog #PROTO14672) |
应用范围 | Cell Culture |
抗体来源 | No |
产品形态 | Sterile Filtered colorless solution. |
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内容 | The ADAM10 solution contains 20mM Tris (pH 8), 1mM EDTA and 50% Glycerol. *可以提供无载体抗体。 |
储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
基因名 | ADAM10 |
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基因全名 | Disintegrin and metalloproteinase domain-containing protein 10 |
蛋白功能 | Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth- like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling. |
Tissue Specificity | Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver. |
Uniprot ID | ADAM10: O14672 |
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