产品名称 | A2M Macroglobulin Alpha-2 Human protein |
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产品描述 | Human Alpha-2 Macroglobulin is a tetrameric glycoprotein, produced in Human plasma and having a molecular mass of 725 kDa. |
文献引用格式 | A2M Macroglobulin Alpha-2 Human protein (Boster Biological Technology, Wuhan, China. Catalog #PROTP01023) |
应用范围 | Cell Culture |
抗体来源 | No |
产品形态 | Sterile Filtered White lyophilized (freeze-dried) powder. |
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内容 | Lyophilized from 0.02M TRIS, 0.15M NaCl and 0.1M Sucrose, pH 8.0. *可以提供无载体抗体。 |
储存条件 | Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles. |
基因名 | A2M |
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基因全名 | Alpha-2-macroglobulin |
蛋白功能 | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
Tissue Specificity | Secreted in plasma. |
Uniprot ID | A2M: P01023 |
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