| 货号 | EK0917-PR |
| 产品名称 | Monkey primate Thrombomodulin PicoKine™ ELISA Kit |
| 产品描述 | Sandwich High Sensitivity ELISA kit for Quantitative Detection of monkey primate Thrombomodulin. 96wells/kit, with removable strips. |
| 免疫原 | Expression system for standard: NSO; Immunogen sequence: A19-S515 |
| 交叉反应 | There is no detectable cross-reactivity with other relevant proteins. |
| 敏感性 | <10pg/ml |
| 检测范围 | 62.5pg/ml-4000pg/ml |
| 基因名称 | THBD |
| 基因全名 | Thrombomodulin |
| Uniprot ID | P07204 |
| 指标别名 | Thrombomodulin;TM;Fetomodulin;CD141;THBD;THRM; |
| 背景资料 | Thrombomodulin(TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is also expressed on monkey primate mesothelial cell, monocyte and a dendritic cell subset. In humans, thrombomodulin is encoded by the THBD gene. The protein has a molecular mass of 74kDa, and consists of a single chain with 5 distinct domains. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. This raises the speed of protein C activation thousandfold. Thrombomodulin-bound thrombin has procoagulant effect at the same time by inhibiting fibrinolysis by cleaving thrombin-activatable fibrinolysis inhibitor(TAFI,aka carboxypeptidase B2) into its active form. Thrombomodulin is a glycoprotein on the surface of endothelial cells that, in addition to binding thrombin, regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene(THBD) have also been reported to be associated with atypical hemolytic-uremic syndrome(aHUS). |
| 显色时间 | 15-20 |
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