货号 | EK0658-PR |
产品名称 | Monkey primate APP PicoKine™ ELISA Kit |
产品描述 | Sandwich High Sensitivity ELISA kit for Quantitative Detection of monkey primate APP. 96wells/kit, with removable strips. |
免疫原 | Expression system for standard: NSO; Immunogen sequence: L18-L688 |
交叉反应 | There is no detectable cross-reactivity with other relevant proteins. |
敏感性 | <100pg/ml |
检测范围 | 312pg/ml-20,000pg/ml |
基因名称 | APP |
基因全名 | Amyloid beta A4 protein |
Uniprot ID | P05067 |
指标别名 | Amyloid beta A4 protein;ABPP;APPI;APP;Alzheimer disease amyloid protein;Cerebral vascular amyloid peptide;CVAP;PreA4;Protease nexin-II;PN-II;N-APP;Soluble APP-alpha;S-APP-alpha;Soluble APP-beta;S-APP-beta;C99;Beta-amyloid protein 42;Beta-APP42;Beta-amyloid protein 40;Beta-APP40;C83;P3(42);P3(40);C80;Gamma-secretase C-terminal fragment 59;Amyloid intracellular domain 59;AICD-59;AID(59);Gamma-CTF(59);Gamma-secretase C-terminal fragment 57;Amyloid intracellular domain 57;AICD-57;AID(57);Gamma-CTF(57);Gamma-secretase C-terminal fragment 50;Amyloid intracellular domain 50;AICD-50;AID(50);Gamma-CTF(50);C31;APP;A4, AD1; |
背景资料 | Amyloid precursor protein(APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity and iron export. APP is best known and most commonly studied as the precursor molecule whose proteolysis generates beta amyloid(Abeta), a 39- to 42-amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. APP undergoes posttranslational proteolytic processing by alpha-, beta-, and gamma-secretases. Alpha-secretase generates soluble amyloid protein, while beta- and gamma-secretases generate APP components with amyloidogenic features. These 2 processing pathways are mutually exclusive. |
显色时间 | 15-20 |