| 货号 | EK0511-EQ |
| 产品名称 | Horse equine TGF Alpha PicoKine™ ELISA Kit |
| 产品描述 | Sandwich High Sensitivity ELISA kit for Quantitative Detection of horse equine TGF alpha. 96wells/kit, with removable strips. |
| 免疫原 | Expression system for standard: E.coli,V40-A89 |
| 交叉反应 | There is cross-reactivity with TGF beta 2, TGF beta 3, TGF beta 5<1%. |
| 敏感性 | <1pg/ml |
| 检测范围 | 15.6pg/ml-1000pg/ml |
| 基因名称 | TGFA |
| 基因全名 | Protransforming growth factor alpha |
| Uniprot ID | P01135 |
| 指标别名 | Protransforming growth factor alpha;Transforming growth factor alpha;TGF-alpha;EGF-like TGF;ETGF;TGF type 1;TGFA; |
| 背景资料 | Transforming growth factor alpha(TGF-alpha) is upregulated in some horse equine cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development. It is closely related to EGF, and can also bind to the EGF receptor with similar effects. TGFalpha stimulates neural cell proliferation in the adult injured brain. Transforming growth factor alpha gene(TGFA) maps to horse equine chromosome 2 close to the breakpoint of the t(2;8) variant translocation in Burkitt lymphoma. Synthetic TGF-alpha was as active as murine epidermal growth factor in binding to the epidermal growth factor receptor and in stimulation of anchorage-dependent and of anchorage-independent growth of normal indicator cells in culture. Synthetic TGF-alpha stimulated plasminogen activator production in A 431 and HeLa cells; the stimulation was similar to that induced by epidermal growth factor. Furthermore, synthetic horse equine TGF-alpha showed similar immunoreactivity when compared with horse equine TGF-alpha. Thus, the 50-amino acid TGF-alpha is likely to be the bioactive principle produced and secreted by tumor cell lines. |
| 显色时间 | 25-30 |
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