货号 | EK2100 |
产品名称 | Rat Legumain PicoKine ELISA Kit |
产品描述 | For quantitative detection of rat Legumain in cell culture supernates, serum and plasma (heparin, EDTA, citrate). |
免疫原 | NSO, V18-N325 |
交叉反应 | There is no detectable cross-reactivity with other relevant proteins. |
敏感性 | <10pg/ml |
检测范围 | 31.2pg/ml-2000pg/ml |
基因名称 | Lgmn |
基因全名 | legumain |
Uniprot ID | Q9R0J8 |
指标别名 | Legumain; Asparaginyl endopeptidase; Protease; cysteine 1; Lgmn; Prsc1 |
背景资料 | Legumain is a protein that in humans is encoded by the LGMN gene. It is mapped to 6q32. This gene encodes a cysteine protease, legumain, that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. |
显色时间 | 15-20 |