货号 | EK2074 |
产品名称 | Rat GFRA2 PicoKine ELISA Kit |
产品描述 | For quantitative detection of rat GFRA2 in cell culture supernates, serum and plasma (heparin, EDTA, citrate). |
免疫原 | NSO, S22-S443 |
交叉反应 | There is no detectable cross-reactivity with other relevant proteins. |
敏感性 | <50pg/ml |
检测范围 | 312pg/ml-20000pg/ml |
基因名称 | Gfra2 |
基因全名 | GDNF family receptor alpha 2 |
Uniprot ID | O35977 |
指标别名 | GDNF family receptor alpha; Gfra2; GDNFR-beta; rCG_37079 |
背景资料 | GDNF family receptor alpha-2 (GFRα2), also known as the neurturin receptor, is a protein that in humans is encoded by the GFRA2 gene. It is mapped to 15p11. The GFRA2 protein is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. They both bind the GFRA2 receptor. The receptor mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. GFRA2 (gene) has been shown to interact with GDNF. |
显色时间 | 15-20 |