货号 | EK2007 |
产品名称 | Mouse TNFRSF22 PicoKine ELISA Kit |
产品描述 | For quantitative detection of mouse TNFRSF22 in cell culture supernates, serum and plasma (heparin, EDTA, citrate). |
免疫原 | NSO, E42-R198 |
交叉反应 | There is no detectable cross-reactivity with other relevant proteins. |
敏感性 | <10pg/ml |
检测范围 | 15.6pg/ml-1000pg/ml |
基因名称 | Tnfrsf22 |
基因全名 | tumor necrosis factor receptor superfamily, member 22 |
Uniprot ID | Q9ER62 |
指标别名 | Tumor necrosis factor receptor superfamily member 22; Decoy TRAIL receptor 2; TNF receptor family member SOBa; TNF receptor homolog 2; Tumor necrosis factor receptor p60 homolog 2; Tnfrsf22; Dctrailr2; Tnfrh2; Tnfrsf1al2 |
背景资料 | TNFRSF22 interacts via a complex receptor system to preferentially induce apoptosis of tumor cells in vivo and in vitro. This gene is mapped to 7 F5; 7 88.27 cM. The mouse decoy TRAIL R2(TNFRSF22) gene encodes a 198 amino acid (aa) residues type I transmembrane protein with a putative 39 aa signal peptide, a 136 aa extracellular domain, a 18 aa transmembrane region, and a 5 aa cytoplasmic tail. An alternatively spliced variant encoding a secreted soluble receptor of 180 aa has also been described. The transmembrane and soluble receptors are known as mDcTRAIL R2L and mDcTRAIL R2S, respectively. Both mDcTRAIL R2 isoforms and the GPI-linked mDcTRAIL R1 bind TRAIL specifically but are incapable of triggering signal transduction. Mouse DcTRAIL R1 and mDcTRAIL R2 share 71% sequence identity. The two receptors have similar structural modules in their CRDs, which differ from those found in the CRDs of mTNF RH3. Mouse DcTRAIL R1 preferentially binds mTRAIL while mDcTRAIL R2 binds both human and mTRAIL. mRNA of mouse DcTRAIL R1 and -2 are expressed at low levels in many mouse tissues and at higher levels in several mouse cell lines. |
显色时间 | 15-20 |