货号 | EK1266 |
产品名称 | Mouse Myostatin/GDF8 PicoKine ELISA Kit |
产品描述 | For quantitative detection of mouse Myostatin/GDF8 in cell culture supernates, tissue, serum and plasma(heparin, EDTA). |
免疫原 | NSO, D268-S376 |
交叉反应 | There is no detectable cross-reactivity with other relevant proteins. |
敏感性 | <10pg/ml |
检测范围 | 31.2pg/ml-2000pg/ml |
基因名称 | Mstn |
基因全名 | myostatin |
Uniprot ID | O08689 |
指标别名 | Growth/differentiation factor 8; GDF-8; Myostatin; Mstn; Gdf8 |
背景资料 | Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. It is mapped to 1 C1.1; 1 26.99 cM. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. |
显色时间 | 15-20 |