货号 | EK2047 |
产品名称 | Mouse CLEC4F PicoKine ELISA Kit |
产品描述 | For quantitative detection of mouse CLEC4F in cell culture supernates, serum and plasma (heparin, EDTA, citrate). |
免疫原 | NSO, R70-G548 |
交叉反应 | There is no detectable cross-reactivity with other relevant proteins. |
敏感性 | <50pg/ml |
检测范围 | 625pg/ml-40000pg/ml |
基因名称 | CLEC4F |
基因全名 | C-type lectin domain family 4, member f |
Uniprot ID | Q8N1N0 |
指标别名 | C-type lectin domain family 4 member F; C-type lectin superfamily member 13; C-type lectin 13; CLEC4F; CLECSF13 |
背景资料 | C-type lectin domain family 4 member F is a protein that in humans is encoded by the CLEC4F gene. This gene is mapped to 6; 6 C3. CLEC4F is an 80 kDa, type II transmembrane glycoprotein member of the C-type lectin superfamily. Mature mouse CLEC4F consists of a 42 amino acid (aa) cytoplasmic domain, a 27 aa transmembrane segment, and a 479 aa extracellular domain that contains an extended stalk region plus one carbohydrate recognition domain. Within the ECD, mouse CLEC4F shares 48% and 79% aa sequence identity with human and rat CLEC4F, respectively. The stalk region of CLEC4F is a coiled coil domain that mediates homotrimer formation. CLEC4F is expressed on Kupffer cells in the liver, but not on macrophages in other tissues. CLEC4F preferentially binds galactose and N‑acetylgalactosamine in a calcium-dependent manner. Its activity at neutral, but not at acidic pH, suggests a capacity to internalize and release ligands into the endosomal system. |
显色时间 | 15-20 |