货号 | EK1686 |
产品名称 | Human ULBP3 PicoKine ELISA Kit |
产品描述 | For quantitative detection of human ULBP3 in cell culture supernates, serum and plasma (heparin, EDTA). |
免疫原 | NSO, D30-G217 |
交叉反应 | There is no detectable cross-reactivity with other relevant proteins. |
敏感性 | <50pg/ml |
检测范围 | 62.5pg/ml-4000pg/ml |
基因名称 | ULBP3 |
基因全名 | UL16 binding protein 3 |
Uniprot ID | Q9BZM4 |
指标别名 | UL16-binding protein 3; ALCAN-gamma; NKG2D ligand 3; N2DL-3; NKG2DL3; Retinoic acid early transcript 1N; ULBP3; N2DL3; RAET1N |
背景资料 | UL16 binding protein 3 (ULBP3) is a cell surface glycoprotein encoded by ULBP3 gene located on the chromosome 6. It is mapped to 6q25.1. ULBP3 is related to MHC class I molecules, but its gene maps outside the MHC locus. The domain structure of ULBP3 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP3 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor. It functions as a stress-induced ligand for NKG2D receptor. The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. |
显色时间 | 20-25 |