货号 | EK2060 |
产品名称 | Human SEMA6D PicoKine ELISA Kit |
产品描述 | For quantitative detection of human SEMA6D in cell culture supernates, serum and plasma (heparin, EDTA, citrate). |
免疫原 | NSO, V21-N662 |
交叉反应 | There is no detectable cross-reactivity with other relevant proteins. |
敏感性 | <20pg/ml |
检测范围 | 31.2pg/ml-2000pg/ml |
基因名称 | SEMA6D |
基因全名 | semaphorin 6D |
Uniprot ID | Q8NFY4 |
指标别名 | Semaphorin-6D; SEMA6D; KIAA1479 |
背景资料 | Semaphorin 6D (Sema6D) is a 130 ‑ 135 kDa member of the Semaphorin family of axon guidance molecules. This gene is mapped to 15q21.1. Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. |
显色时间 | 15-20 |