货号 | EK2065 |
产品名称 | Human PLA2G4A PicoKine ELISA Kit |
产品描述 | For quantitative detection of human PLA2G4A in cell culture supernates, serum and plasma (heparin, EDTA, citrate). |
免疫原 | NSO, M1-A749 |
交叉反应 | There is no detectable cross-reactivity with other relevant proteins. |
敏感性 | <50pg/ml |
检测范围 | 62.5pg/ml-4000pg/ml |
基因名称 | PLA2G4A |
基因全名 | phospholipase A2 group IVA |
Uniprot ID | P47712 |
指标别名 | Cytosolic phospholipase A2; Cpla2; Phospholipase A2 group IVA; Phospholipase A2; Phosphatidylcholine 2-acylhydrolase; Lysophospholipase; PLA2G4A; CPLA2; PLA2G4 |
背景资料 | Cytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene. It is mapped to 1q31.1. This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. |
显色时间 | 15-20 |