货号 | EK1765 |
产品名称 | Human PAM PicoKine ELISA Kit |
产品描述 | For quantitative detection of human PAM in cell culture supernates, serum and plasma (heparin, EDTA, citrate). |
免疫原 | NSO, M1-V817 |
交叉反应 | There is no detectable cross-reactivity with other relevant proteins. |
敏感性 | <50pg/ml |
检测范围 | 312pg/ml-20000pg/ml |
基因名称 | PAM |
基因全名 | peptidylglycine alpha-amidating monooxygenase |
Uniprot ID | P19021 |
指标别名 | Peptidyl-glycine alpha-amidating monooxygenase; PAM; Peptidylglycine alpha-hydroxylating monooxygenase (EC:1.14.17.3); PHM; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC:4.3.2.5); Peptidylamidoglycolate lyase; PAL; PAM |
背景资料 | Peptidyl-glycine alpha-amidating monooxygenase is an enzyme that catalyzes the biosynthesis of many signaling peptides and, in humans, is encoded by the PAM gene. It is mapped to 5q21.1. This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
显色时间 | 15-20 |