货号 | EK1999 |
产品名称 | Human Nephrin PicoKine ELISA Kit |
产品描述 | For quantitative detection of human Nephrin in cell culture supernates, serum and plasma (heparin, EDTA, citrate). |
免疫原 | NSO, Q23-S1055 |
交叉反应 | There is no detectable cross-reactivity with other relevant proteins. |
敏感性 | <50pg/ml |
检测范围 | 156pg/ml-10000pg/ml |
基因名称 | NPHS1 |
基因全名 | NPHS1, nephrin |
Uniprot ID | O60500 |
指标别名 | Nephrin; Renal glomerulus-specific cell adhesion receptor; NPHS1; NPHN |
背景资料 | Nephrin is a protein necessary for the proper functioning of the renal filtration barrier. It is mapped to 19q13.12. This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes. |
显色时间 | 20-25 |