货号 | EK1952 |
产品名称 | Human GIF PicoKine ELISA Kit |
产品描述 | For quantitative detection of human GIF in cell culture supernates, serum and plasma (heparin, EDTA, citrate). |
免疫原 | NSO, S19-Y417 |
交叉反应 | There is no detectable cross-reactivity with other relevant proteins. |
敏感性 | <10pg/ml |
检测范围 | 15.6pg/ml-1000pg/ml |
基因名称 | CBLIF |
基因全名 | cobalamin binding intrinsic factor |
Uniprot ID | P27352 |
指标别名 | Cobalamin binding intrinsic factor; Gastric intrinsic factor; Intrinsic factor; IF; INF; CBLIF; GIF |
背景资料 | Intrinsic factor (IF), also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B12 later on in the ileum of the small intestine. In humans, the gastric intrinsic factor protein is encoded by the GIF gene. It is mapped to 11q12.1. Haptocorrin (also known as HC, R protein, and transcobalamin I, TCN1) is another glycoprotein secreted by the salivary glands which binds to vitamin B12. Vitamin B12 is acid sensitive and in binding to transcobalamin I it can safely pass through the acidic stomach to the duodenum. In the less acidic environment of the small intestine, pancreatic enzymes digest the glycoprotein carrier and vitamin B12 can then bind to intrinsic factor |
显色时间 | 15-20 |