货号 | EK1965 |
产品名称 | Human Cystatin M/CST6 PicoKine ELISA Kit |
产品描述 | For quantitative detection of human Cystatin M/CST6 in cell culture supernates, serum and plasma (heparin, EDTA). |
免疫原 | E.coli, R29-M149 |
交叉反应 | There is no detectable cross-reactivity with other relevant proteins. |
敏感性 | <10pg/ml |
检测范围 | 46.9pg/ml-3000pg/ml |
基因名称 | CST6 |
基因全名 | cystatin E/M |
Uniprot ID | Q15828 |
指标别名 | Cystatin-M; Cystatin-6; Cystatin-E; CST6 |
背景资料 | Cystatin-M is a protein that in humans is encoded by the CST6 gene. It is mapped to 11q13.1. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. |
显色时间 | 20-25 |