货号 | EK1986 |
产品名称 | Human CILP PicoKine ELISA Kit |
产品描述 | For quantitative detection of human CILP in cell culture supernates, serum and plasma (heparin, EDTA, citrate). |
免疫原 | NSO, M1-R720 |
交叉反应 | There is no detectable cross-reactivity with other relevant proteins. |
敏感性 | <50pg/ml |
检测范围 | 93.8pg/ml-6000pg/ml |
基因名称 | CILP |
基因全名 | cartilage intermediate layer protein |
Uniprot ID | O75339 |
指标别名 | Cartilage intermediate layer protein 1; CILP-1; Cartilage intermediate-layer protein; CILP; UNQ602/PRO1188 |
背景资料 | Cartilage intermediate layer protein 1 is a protein that in humans is encoded by the CILP gene. It is mapped to 15q22.31. Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. |
显色时间 | 15-20 |