最初从Heloderma suspectum毒液中分离的毒蜥外泌肽-4刺激腺泡cAMP而不引起淀粉酶释放,以类似于胰高血糖素样肽1受体的亲和力结合,并用于治疗2型糖尿病。
序列(三个字母) | His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
序列(一个字母) | HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 |
CAS | [141758-74-9] |
纯度 | ≥95.0% |
分子量 | 4187.6 |
Description | Exendin-4, originally isolated from Heloderma suspectum venom, stimulates acinar cAMP without causing amylase release, binds with similar affinity to the glucagon-like peptide 1 receptor, and is used in the treatment of type 2 diabetes. |
Formula | C184H282N50O60S1 |
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