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含有肾上腺髓质素NH2-末端20肽（PAMP）的肾上腺髓质素前体，独特的20个残基序列。 PAMP在麻醉的大鼠中产生强烈且快速的降压作用。 PAMP也被认为可作为肾脏去甲肾上腺素能神经传递的抑制性调节剂，从而在调节肾功能方面发挥重要作用。 已提出PAMP用作体内肾上腺儿茶酚胺释放的抑制性调节剂，并且在禁食小鼠的脑内三次给药后具有有效的高血糖效应。
| 序列(三个字母） | Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2 |
| 序列（一个字母） | ARLDVASEFRKKWNKWALSR-NH2 |
| CAS | [150238-87-2] |
| 纯度 | ≥95.0% |
| 分子量 | 2461.8 |
| Description | Precursor of adrenomedullin containing proadrenomedullin NH2-terminal 20 peptide (PAMP), a unique 20-residue sequence. When administered, PAMP produces a strong and rapid hypotensive effect in anesthetized rats. PAMP has also been suggested to function as an inhibitory modulator of renal noradrenergic neurotransmission, thereby playing an important role in the regulation of renal functions. PAMP has been proposed to serve as an inhibitory regulator in ?adrenal catecholamine release in vivo and possesses a potent hyperglycemic effect after intra-third cerebroventricular administration in fasted mice. |
| Formula | C112H178N36O27 |
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