Milliplex Catalog ID.RLI1MAG-92K-05.Rat

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Milliplex Catalog ID.RLI1MAG-92K-05.Rat

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货号：RLI1MAG-92K-05

品牌：Millipore 密理博

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北京朝阳

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Replacement Information

重要规格表

Analytes Available	Species Reactivity	Key Applications	Detection Methods
ARG1, GOT1, GSTα, SDH, 5'-NT/CD73	R	Mplex	Luminex xMAP

Description
Catalogue Number	RLI1MAG-92K
Trade Name	MILLIPLEX
Description	MILLIPLEX MAP Rat Liver Injury Panel - Toxicity Multiplex Assay
Overview	The MILLIPLEX® MAP Rat Liver Injury Magnetic Bead Panel (RLI1MAG-92K) contains all the components necessary to simultaneous quantify the following 5 analytes in serum and plasma samples: • Liver-Type Arginase 1 (ARG1)* • Aspartate transaminase 1 (GOT1) • α-glutathione S-transferase (GSTα)* • Sorbitol Dehydrogenase (SDH)* • 5'-Nucleotidase/CD73 (5’-NT) *ARG1, GSTα, and SDH are biomarkers listed in the Predictive Safety Testing Consortium (PSTC) project pipeline which have a strong translational role in drug safety testing. EMD Millipore provides a valuable research assay to investigate multiple biomarkers of liver injury in rat serum and plasma samples using the Luminex xMAP® instrument platform. This kit uses a 96-well format, contains a lyophilized standard cocktail, two quality controls and can measure up to 38 serum or plasma samples in duplicate.
Background Information	Drug toxicity is the leading cause of acute liver failure in the United States. Patients with liver damage generally display elevated amounts of specific liver proteins in serum; these proteins can serve as biomarkers of drug-related liver toxicity. Monitoring these biomarkers can greatly help clinicians avoid drug-induced liver failure. Performing laboratory tests to characterize the side effects of potential therapeutics is an essential part of drug development. The rat is a leading animal model for these pre-clinical toxicity studies. The search for sensitive, organ-specific toxicity biomarkers is complemented by the development of novel assays to measure these critical analytes. Liver-Type Arginase 1 (ARG1), α-glutathione S-transferase (GSTα), and Sorbitol Dehydrogenase (SDH) are biomarkers listed in the Predictive Safety Testing Consortium (PSTC) project pipeline which have a strong translational role in drug safety testing. Aspartate transaminase 1 (GOT1) and 5'-Nucleotidase / CD73 (5’-NT) are traditional biomarkers recognized by both the Food and Drug Administration (FDA) and its European counterpart, the European Medicines Agency (EMA).

References

Product Information
Components	Rat Liver Injury Standard, 1 vial, lyophilized Rat Liver Injury Quality Control 1, 1 vial, lyophilized Rat Liver Injury Quality Control 2, 1 vial, lyophilized Assay Buffer, 1 bottle, 30 mL Wash Buffer, 10X (0.05% Proclin), 2 bottles, 30 mL ea Rat Liver Injury Detection Antibodies, 1 bottle, 3.2 mL Streptavidin-Phycoerythrin, 1 bottle, 3.2 mL Mixing Bottle, 1 bottle Sample Plate, 96 well format, 1 plate 2 Foil Plate Sealers
Detection method	Luminex xMAP
Configuration	Design your multiplex kit by choosing available analytes within this panel.
Precision, %	Inter-assay: <15 Intra-assay: <10
Panel Type	MAGNETIC Toxicity

Applications
Application	The analytes available for this multiplex kit are: Liver-type arginase 1 (ARG1), aspartate transaminase 1 (GOT1), α-glutathianone S-transferase (GSTα), sorbitol dehydrogenase (SDH), and 5'-Nucleotidase (5'-NT/CD73).
Key Applications	Multiplexing
Application Notes	• This is an overnight assay. • This assay requires 25 µL of 1:25 diluted serum or plasma sample per well in kit Assay Buffer (please dilute per protocol instructions).

Biological Information
Specificity	There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel.
Species Reactivity	Rat
Analytes Available	ARG1 GOT1 GSTα SDH 5'-NT/CD73
Assay Panel	Everything you need in a single kit.
Cross Reactivity	There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel.
Accuracy	77% - 92%

Physicochemical Information
Sensitivity	0.021 - 4.038 ng/mL (MinDC+2SD). Please see kit protocol for individual assay sensitivities.
Linearity of Dilution	Contact technical support for this information.
Standard Curve Range	ARG1: 0.10 – 75.0 ng/mL GOT1: 0.08 – 60.0 ng/mL GSTα: 0.02 – 15.0 ng/mL SDH: 0.62 – 450.0 ng/mL 5'-NT/CD73: 0.04 – 30.0 ng/mL

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Recommended storage for kit components is 2 - 8°C.

Packaging Information
Material Size	96-well plate

Transport Information

Supplemental Information

Specifications

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Milliplex Catalog ID.RLI1MAG-92K-05.Rat

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