Milliplex Catalog ID.CKT2MAG-97K-04.Cani

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Milliplex Catalog ID.CKT2MAG-97K-04.Cani

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货号：CKT2MAG-97K-04

品牌：Millipore 密理博

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北京朝阳

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Replacement Information

重要规格表

Analytes Available	Species Reactivity	Key Applications	Detection Methods
Albumin, β-2-Microglobulin, Trefoil Factor 3 (TFF-3), Retinol Binding Protein 4 (RBP4)	Ca	Mplex	Luminex xMAP

Description
Catalogue Number	CKT2MAG-97K
Trade Name	MILLIPLEX
Description	MILLIPLEX® MAP Canine Kidney Toxicity Panel 2 - Toxicity Multiplex Assay
Overview	The MILLIPLEX® MAP Canine Kidney Toxicity Panel 2 contains all the components necessary to measure the following four biomarkers in any combination using Luminex® xMAP® technology: Albumin, β-2-microglobulin (B2M), Trefoil Factor 3 (TFF-3), Retinol Binding Protein 4 (RBP4). The kit uses a 96-well format, contains a lyophilized standard cocktail, two quality controls and can measure up to 38 urine samples in duplicate.
Background Information	As one of the leading causes of drug candidate attrition, toxicity research is receiving more attention, especially in the search of sensitive, organ-specific toxicity biomarkers. In pharmaceutical and chemical industries, renal function is routinely assessed during toxicity evaluations. The importance of the kidney as a central detoxification organ leads to a high exposure of renal tissue to drugs, reactive metabolites, and environmental compounds. Traditional markers for assessing renal toxicity, such as blood urea nitrogen (BUN) and serum creatinine, are insensitive and non-specific. For improved, non-invasive detection of acute nephrotoxicity, a panel of novel urinary kidney biomarkers has been identified and validated for preclinical studies in relevant animal species. EMD Millipore provides a valuable research assay to investigate multiple biomarkers of kidney injury in canine urine samples using the Luminex xMAP® instrument platform. The MILLIPLEX® MAP Canine Kidney Toxicity Panel 2 offers simultaneous analysis of any combination of the following analytes: Albumin, β-2-microglobulin (B2M), Trefoil Factor 3 (TFF-3), Retinol Binding Protein 4 (RBP4). *Urinary albumin, B2M, TFF-3 and RBP4 are biomarkers listed in the Predictive Safety Testing Consortium (PSTC) project pipeline which have a strong translational role in drug safety testing.

References

Product Information
Components	Canine Kidney Toxicity Panel 2 Standard, 1 vial, lyophilized Canine Kidney Toxicity Panel 2 Control 1, 1 vial, lyophilized Canine Kidney Toxicity Panel 2 Control 2, 1 vial, lyophilized Assay Buffer, 2 bottles, 30 mL Wash Buffer, 10X (0.05% Proclin), 2 bottlesl, 30 mL Canine Kidney Toxicity Panel 2 Detection Antibodies, 1 bottle, 5.5 mL Streptavidin-Phycoerythrin, 1 bottle, 5.5 mL Mixing Bottle, 1 bottle Sample Plate, 96 well format, 1 plate 2 Foil Plate Sealers
Detection method	Luminex xMAP
Configuration	Design your multiplex kit by choosing available analytes within this panel.
Precision, %	Inter-assay: <15 Intra-assay: <10
Panel Type	MAGNETIC Toxicity

Applications
Application	The analytes available for this multiplex kit are: Albumin, β-2-microglobulin (B2M), Trefoil Factor 3 (TFF-3), Retinol Binding Protein 4 (RBP4)
Key Applications	Multiplexing
Application Notes	• Customers should determine the optimal dilution factor for their samples. Our recommendations are based on urine samples from normal subjects. • This assay requires 25 µL of 1:500 diluted urine sample per well in kit Assay Buffer (please dilute per protocol instructions). • This is a 2 hour assay.

Biological Information
Specificity	Approximately 5% cross-reactivity may be observed between B2M beads and TFF-3 protein. No other significant cross-reactivity was observed for other analytes in this panel.
Species Reactivity	Canine
Analytes Available	Albumin β-2-Microglobulin Trefoil Factor 3 (TFF-3) Retinol Binding Protein 4 (RBP4)
Assay Panel	Everything you need in a single kit.
Cross Reactivity	Approximately 5% cross-reactivity may be observed between B2M beads and TFF-3 protein. No other significant cross-reactivity was observed for other analytes in this panel.
Accuracy	96% - 102%

Physicochemical Information
Sensitivity	Albumin: 12.48 ng/mL (MinDC +2SD) All other analytes: 0.016 - 0.026 ng/mL (MinDC +2SD) See kit protocol for individual analyte sensitivities.
Linearity of Dilution	Contact technical support for this information.
Standard Curve Range	Albumin: 12.21 – 50,000 ng/mL B2M: 0.02 – 100 ng/mL TFF-3: 0.02 – 100 ng/mL RBP4: 0.01 – 50 ng/mL

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Recommended storage for kit components is 2 - 8°C.

Packaging Information
Material Size	96-well plate

Transport Information

Supplemental Information

Specifications

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Milliplex Catalog ID.CKT2MAG-97K-04.Cani

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