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Recombinant Human Oncostatin M

市场价：: 0.00

促销价：: ¥0.00

货号：GF016

品牌：Millipore 密理博

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北京朝阳

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Replacement Information

重要规格表

Species	Source	Purity
Human	E.coli	Greater than 98% by SDS-PAGE and HPLC analysis

Description
Catalogue Number	GF016
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Oncostatin M Protein, Recombinant human
Overview	Oncostatin M is an important growth regulating cytokine that affects, variably, a number of tumor and normal cells. Oncostatin M exerts inhibitory effects on the growth of A375 melanoma and other cancer cells but augments the growth of normal fibroblasts, AIDS related Kaposi sarcoma cells, and certain other cells. Human Oncostatin M is a 26 kDa protein containing 227 amino acid residues.

References

Product Information
Presentation	Lyophilized protein with no additives.

Applications
Application	The Oncostatin M protein is an important growth regulating cytokine that affects, variably, a number of tumor & normal cells.
Application Notes	For most in vitro applications, Oncostatin M exerts its biological activity in the concentration range of 0.2 to 20 ng/mL. Responding cells are (partial list): Tumor cells, certain other cells.

Biological Information
Purity	Greater than 98% by SDS-PAGE and HPLC analysis
Source	E.coli
Specific Activity	Human Oncostatin M is fully biologically active when compared to standards. The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is <= 2 ng/mL corresponding to a specific activity of >= 5 x 10(E5) units/mg.
Entrez Gene Number	NM_020530.3
Entrez Gene Summary	Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells.
Gene Symbol	OSM MGC20461
UniProt Number	P13725
UniProt Summary	FUNCTION: SwissProt: P13725 # Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). SIZE: 252 amino acids; 28484 Da SUBCELLULAR LOCATION: Secreted. SIMILARITY: SwissProt: P13725 ## Belongs to the LIF/OSM family.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	The lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute with sterile water to a concentration of 100 ng/uL. This solution can be diluted into other buffered solutions. Reconstituted Oncostatin M should be stored in undiluted aliquots at-20°C for up tp six months.

Packaging Information
Material Size	10 µg

Transport Information

Supplemental Information

Specifications

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