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ENDOTHELIN 1, HUMAN AND PORCINE

市场价：: 0.00

促销价：: ¥0.00

货号：05-23-3800-1MG

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₁₀₉H₁₅₉N₂₅O₃₂S₅	117399-94-7

Description
Overview	A 21-amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca²⁺ channels. Reported to activate phospholipase C in fibroblasts expressing ET_A receptors.
Catalogue Number	05-23-3800
Brand Family	Calbiochem®
Synonyms	ET-1, CSCSSLMDKECVYFCHLDIIW

References
References	Cesari, M., et al. 1996. Am. Heart J. 132, 1236. Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169. Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524. Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294. Itoh, Y., et al. 1988. FEBS Lett. 231, 440. Yanagisawa, M., et al. 1988. Nature 332, 411.

Product Information
CAS number	117399-94-7
ATP Competitive	N
Form	White to off-white solid
Formulation	Supplied as an acetate salt.
Hill Formula	C₁₀₉H₁₅₉N₂₅O₃₂S₅
Chemical formula	C₁₀₉H₁₅₉N₂₅O₃₂S₅
Reversible	N
Sold on the basis of peptide content	Y

Applications

Biological Information
Primary Target	Potent vasoconstrictive action
Purity	≥96% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Content	Y
Peptide Sequence	H-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Packaging Information

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Supplemental Information

Specifications

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