Complement C5b,6 Complex, Human - 炼石商城

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Complement C5b,6 Complex, Human

市场价：: 0.00

促销价：: ¥0.00

货号：204906-50UG

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

Description
Overview	Native, human C5b,6 complement component complex. Activation of complement by either pathway results in the formation of C5-cleaving enzymes (C5 convertases) on target surfaces. The C5 convertase enzymes cleave the C5 α-chain at peptide bond 74, resulting in the formation of the C5a anaphylatoxin (M.W. 11,200) and the C5b fragment (M.W. 185,000). The nascent C5b fragment can combine with C6, C7, C8, and C9 to form the lytic C5b-9 membrane attack complex on target surfaces. When C5 activation occurs in the presence of C6 only, e.g. in C7 deficient serum, a stable C5b,6 complex is formed. In a process termed Reactive Lysis, the membrane attack complex can be assembled on target cell surfaces in the absence of any additional complement proteins by incubating target cells with the C5b,6 complex and purified C7, C8, and C9.
Catalogue Number	204906
Brand Family	Calbiochem®

References
References	Podack, E.R., et al. 1978. J. Immunol. 120, 1841. Lachmann, P.J. and Thompson, R.A. 1970. J. Exp. Med. 131, 643.

Product Information
Form	Liquid
Formulation	In 120 mM NaCl, 10 mM HEPES, pH 7.2.

Applications

Biological Information
Purity	≥95% by SDS-PAGE
Source	Prepared from plasma of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity	≥2000 C5b,6H50 units/mg
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).

Packaging Information

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Supplemental Information

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