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Qiagen 凯杰 Biosharp Omega

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Complement C5, Human

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号:204888-250UG

牌:Millipore 密理博

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      塑胶安瓿;塑胶针药瓶 250 μg
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      Description
      Overview Native, human C5 complement component. Glycoprotein composed of two non-identical subunits of M.W. 120 kDa (α) and 75 kDa (β) linked by disulfide bonds. Present in normal human serum at 70 µg/ml. Activation of complement via either the classical or alternative pathway can result in the assembly of C5-cleaving enzymes (C5 convertases) on target surfaces. Both C5 convertases cleave the C5 α-chain at peptide bond 74 resulting in production of C5a (M.W. 11,200) and C5b fragments (M.W. 185,000). Released C5a peptide is one of the three complement-derived anaphylatoxins. C5b fragment combines with C6, C7, C8, and C9 to form lytic C5b-9 complement membrane attack complex (MAC).
      Catalogue Number 204888
      Brand Family Calbiochem®
      References
      References Janatova, J. 1988. Methods Enzymol. 162, 579.
      Wetsel, R.A., et al. 1980. J. Immunol. Methods 35, 319.
      Product Information
      CAS number 80295-53-0
      Form Liquid
      Formulation In PBS, pH 7.2.
      Applications
      Biological Information
      Biological activity ≥100,000 C₅H₅0 units/mg; ≥60% of the C5 activity in normal human serum on a mg/mg basis
      Purity ≥95% by SDS-PAGE
      Source Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Contaminants IgG, IgA, IgM, albumin, ceruloplasmin or functionally C3, C6, C7, C8, or C9: ≤trace amounts
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special Instructions Following initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

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