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Complement C4, Human

市场价：: 0.00

促销价：: ¥0.00

货号：204886-250UG

品牌：Millipore 密理博

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北京朝阳

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Description
Overview	Native, human C4 complement component. Glycoprotein composed of three non-identical subunits of M.W. of 93 kDa (α), 75 kDa (β), and 32 kDa (γ) linked by disulfide bonds. Present in normal human serum at 400 µg/ml. On activation of complement via the classical pathway, the C1s subcomponent of the C1 complex is converted to an active serine protease that cleaves the C4 α-chain at peptide bond 77, resulting in production of C4a (M.W. 8740) and C4b fragments (M.W. 193 kDa). The released C4a peptide is one of the three complement-derived anaphylatoxins. The nascent C4b fragment can form a covalent ester bond with target surfaces. This covalent attachment of C4b to target acceptors is required for continuation of activation via classical pathway.
Catalogue Number	204886
Brand Family	Calbiochem®

References
References	Janatova, J. 1983. Ann. N.Y. Acad. Sci. 421, 218. Hammer, C.H., et al. 1981. J. Biol. Chem. 256, 3995.

Product Information
CAS number	80295-48-3
Form	Liquid
Formulation	In PBS, pH 7.2.

Applications

Biological Information
Biological activity	≥60% of the C4 activity present in freshly drawn normal human serum on a mg to mg basis
Purity	≥90% by SDS-PAGE
Source	Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity	>3X10⁵ C4H50 units/mg
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information

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Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).

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