Complement C1s, Human, Activated, Two-Chain Form - 炼石商城

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Complement C1s, Human, Activated, Two-Chain Form

市场价：: 0.00

促销价：: ¥0.00

货号：204879-250UG

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

Description
Overview	Native, human, activated C1s complement component. Present in human serum at 31 µg/ml. Nonactivated C1s is found in circulating blood plasma as a Ca²⁺-dependent dimer in association with one C1q molecule and two C1r molecules to form the first component of complement (C1). Ensuing C1q binding to classical complement pathway activators, each C1r protein is cleaved to form activated C1r enzyme. Dimeric C1r enzyme cleaves, and thus activates, each C1s molecule into two disulfide-linked fragments of M.W. 59 kDa and 28 kDa. The 28 kDa peptide contains the C1s enzymatic active site. Activated C1s continues activation via classical pathway by cleaving, and thus activating, C2 and C4.
Catalogue Number	204879
Brand Family	Calbiochem®

References
References	Cooper, N.R. 1985. Adv. Immunol. 37, 151. Sim, R.B. 1981. Methods Enzymol. 80, 6.

Product Information
CAS number	80295-35-8
Form	Liquid
Formulation	In 130 mM NaCl, 50 mM sodium phosphate, pH 7.2.

Applications

Biological Information
Purity	≥95% by SDS-PAGE
Source	Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).

Packaging Information

Transport Information

Supplemental Information

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