Complement C1r, Human, Activated, Two-Chain Form - 炼石商城

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Complement C1r, Human, Activated, Two-Chain Form

市场价：: 0.00

促销价：: ¥0.00

货号：204878-250UG

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Description
Overview	Native, human, activated, C1r complement component. Generally the non-activated form composed of a single-chain glycoprotein. Present in normal human serum at 34 µg/ml. Non-activated C1r is found in circulating blood plasma as a dimer that associates with one C1q molecule and two C1s molecules to form the first component of complement (C1). Ensuing C1q binding to classical complement pathway activators, each C1r proenzyme monomer is activated by cleavage into two disulfide-linked fragments of M.W. 60,000 and 35,000. The 35 kDa peptide contains C1r enzymatic active site. Activated C1r continues activation via classical pathway by cleaving, and thus activating C1s.
Catalogue Number	204878
Brand Family	Calbiochem®

References
References	Villiers, C.L., et al. 1983. Biochem. J. 215, 369. Ziccardi, R.J. and Cooper, N.R. 1976. J. Immunol. 116, 496.

Product Information
CAS number	80295-34-7
Form	Liquid
Formulation	In 140 mM NaCl, 10 mM imidazole, 2 mM EDTA, pH 7.4.

Applications

Biological Information
Biological activity	≥90% of C1r will bind with excess C1-INH
Purity	≥90% by SDS-PAGE
Source	Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information
Contaminants	IgG, IgA, IgM, albumin, C1s, C4BP, C1-INH: ≤trace amounts

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).

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