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Complement C1q, Human

市场价：: 0.00

促销价：: ¥0.00

货号：204876-1MG

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

Description
Overview	Native, human C1q complement component. Glycoprotein composed of 18 polypeptide chains consisting of three nonidentical subunits, A, B, and C, of M.W. 29 kDa, 26 kDa, and 19 kDa, respectively. Present in normal human serum at 70 µg/ml. Found in circulating blood plasma complexed with two C1r and two C1s molecules to form the first component of complement (C1). Activation of complement via classical pathway is triggered by binding of C1q to immune complexes containing IgG or IgM or to a variety of other activating substances, including C-reactive protein, retroviruses, and mitochondria. Subsequent to C1q binding, C1r and C1s are converted to proteolytic enzymes that are responsible for continuation of activation via the classical pathway.
Catalogue Number	204876
Brand Family	Calbiochem®

References
References	Loos, M., et al. 1980. J. Immunol. 124, 59. Kolb, W.P., et al. 1979. J. Immunol. 122, 2103.

Product Information
CAS number	80295-33-6
Form	Liquid
Formulation	In 300 mM NaCl, 10 mM HEPES, 40% glycerol, pH 7.2.

Applications

Biological Information
Biological activity	≥150,000 C1qH50 units/mg and ≥70% C1q activity in normal human serum on a mg/mg basis
Purity	≥90% by SDS-PAGE
Source	Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information
Contaminants	IgG, IgA, IgM, C3, C4, albumin, fibrinogen, α₂-macroglobulin: ≤trace amounts

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).

Packaging Information

Transport Information

Supplemental Information

Specifications

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