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Wortmannin, (PI3 Kinase inhibitor)

市场价：: 0.00

促销价：: ¥0.00

货号：12-338

品牌：Millipore 密理博

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Description
Catalogue Number	12-338
Brand Family	Upstate
Trade Name	Upstate
Description	Wortmannin, (PI3 Kinase inhibitor)
Overview	Wortmannin, a fungal metabolite, is a cell-permeable, irreversible inhibitor of phosphatidylinositol 3 kinase (PI3 Kinase) with an IC50 of 5nM. It blocks the catalytic activity of PI3-Kinase without affecting upstream signaling events such as insulin receptor tyrosine kinase activity. Wortmannin also inhibits the activities of myosin light chain kinase and PI4-Kinase at concentrations a hundred times higher than those required to inhibit PI3-Kinase.

References

Product Information
Presentation	1mg of lyophilized powder packaged under inert gas. White to off-white powder.

Applications
Application	The Wortmannin, (PI3 Kinase inhibitor) controls the biological activity of PI3 Kinase. This small molecule/inhibitor is primarily used for Biochemicals applications.
Key Applications	Kinase Assay

Biological Information
Entrez Gene Number	NM_014308.2
Entrez Gene Summary	Receptor-regulated class I phosphoinositide 3-kinases (PI3Ks) phosphorylate the membrane lipid phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to PtdIns(3,4,5)P3, which in turn recruits and activates cytosolic effectors involved in proliferation, survival, or chemotaxis. PIK3R5 is a PI3K regulatory subunit (Brock et al., 2003 [PubMed 12507995]).[supplied by OMIM]
Gene Symbol	PIK3R5 P101-PI3K FOAP-2 F730038I15Rik
Protein Target	PI3Kγ
Target Sub-Family	PI3K/PI4K
UniProt Number	Q8WYR1
UniProt Summary	FUNCTION: SwissProt: Q8WYR1 # Regulatory subunit of the PI3K gamma complex. SIZE: 880 amino acids; 97348 Da SUBUNIT: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with G beta gamma proteins. SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). TISSUE SPECIFICITY: Highly expressed in leukocytes, followed by spleen, lymph node, thymus ans bone marrow. DOMAIN:SwissProt: Q8WYR1 The heterodimerization region allows the binding to the catalytic subunit. SIMILARITY:

Physicochemical Information

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Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Routinely evaluated by kinase assay. Purity: ≥95% by HPLC. Molecular Formula: C₂₃H₂₄O₈ Molecular Weight: 428.4
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Protect from light. Stable for 2 years as supplied at -20°C. Following reconstitution aliquot and store at -20°. The DMSO/ethanol stock solutions are stable for 1-3 months at -20°C.

Packaging Information
Material Size	1 mg

Transport Information

Supplemental Information

Specifications

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