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Qiagen 凯杰 Biosharp Omega

首页细胞生物学检测Millipore 密理博>

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Ready-to-Assay™ MC5 Melanocortin Family Receptor Frozen Cells.

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货号：HTS155RTA

品牌：Millipore 密理博

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Replacement Information

特卖

This product requires a User Agreement (Label License). Please see product datasheet for further information

重要规格表

Species Host Cells Protein Target
Human Chem-10 MC5
Description
Catalogue Number HTS155RTA
Trade Name
  • Ready-to-Assay
Description Ready-to-Assay™ MC5 Melanocortin Receptor Frozen Cells
Background Information Millipore’s Ready-to-Assay GPCR frozen cells are designed for simple, rapid calcium assays with no requirement for intensive cell culturing. Millipore has optimized the freezing conditions to provide cells with high viability and functionality post-thaw. The user simply thaws the cells and resuspends them in media, dispenses cell suspension into assay plates and, following over night recovery, assays for calcium response.

The melanocortin system consists of five seven-transmembrane spanning G-protein coupled receptors, MC1-MC5 (Gantz and Fong, 2003). Among the five members of the melanocortin receptor family, MC2 and MC5 are expressed in peripheral tissues. The MC2 receptor (ACTH receptor) is almost exclusively expressed in the adrenal cortex whereas MC5 is expressed in several organs including the adrenal cortex. Studies have shown that targeted disruption of the MC5R gene produced mice with a severe defect in water repulsion and thermoregulation caused by decreased production of sebaceous lipids (Chen et al., 1997). In addition, MC5 is required for secretion from several exocrine glands, indicating that melanocortin peptides integrate the function of exocrine glands (Entwistle et al., 1990). Millipore’s cloned human MC5 -expressing cell line is made in the Chem-10 host, which supports high levels of recombinant MC5 expression on the cell surface and contains optimized levels of a recombinant promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists, antagonists, and modulators at MC5.
References
Product Information
Components
  • Pack contains 2 vials of mycoplasma-free cells, 1 ml per vial.
  • Fifty (50) mL of Media Component.
Detection method Fluorescent
Applications
Application Human MC5 GPCR frozen cells for Calcium Flux FLIPR Assays.
Key Applications
  • Calcium Flux Assays
Biological Information
Entrez Gene Number
GPCR Class A
Host Cells Chem-10
Protein Target MC5
Target Sub-Family Melanocortin
Cell Line Type
  • GPCR Cell Lines
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck to request certain information about you and the establishment where the GMOs are being handled. Click here for Enduser Declaration (EUD) Form.
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size 1 kit
Transport Information
Supplemental Information
Specifications

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