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Qiagen 凯杰 Biosharp Omega

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Long S6 Kinase Substrate Peptide

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货号：12-420

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 12-420
Brand Family Upstate
Trade Name
  • Upstate
Description Long S6 Kinase Substrate Peptide
References
Product Information
Presentation Lyophilized
Applications
Key Applications
  • Kinase Assay
Biological Information
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Gene Symbol
  • RPS6KA1
  • pp90RSK1
  • HU-1
  • RSK-1
  • MAPKAPK1A
  • p90S6K
  • RSK1
  • RSK
Protein Target p70S6K
Target Sub-Family AGC
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q15418 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
COFACTOR: Magnesium.
SIZE: 735 amino acids; 82723 Da
SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.
PTM: Autophosphorylated on Ser-380, as part of the activation process.
SIMILARITY: SwissProt: Q15418 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated as a substrate for ROK (Catalogue No. 14-338) and other kinases.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at 4°C
Packaging Information
Material Size 1 mg
Transport Information
Supplemental Information
Specifications

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