[关闭]
您好！欢迎来到炼石商城   请登录  注册    兼职小伙伴  
我的购物车
0
Qiagen 凯杰 Biosharp Omega

首页克隆与表达Millipore 密理博>

图片仅供参考，请以实物为准
收藏

A SYP/SHPTP2,RAB PC 12-301

市场价：
0.00
促销价：
¥0.00

货号：06-118

品牌：Millipore 密理博

配送至：

支付： 账期 货到付款

数量：

EA (预计3-5工作日到货)

亲，想了解价格请QQ咨询客服！

工作时间

周一至周五：9:00-18:00

咨询电话

0771-3293894

在线咨询

客服 郭恒 蔡玉坤 曾宪飞 技术咨询

浏览了该商品的用户最终购买

RNeasy Mini Kit (50) 50次
RNeasy Mini Kit (50) 50次
3720.00
Plasmid Mini Kit I(200) 200次
Plasmid Mini Kit I(200) 200...
576.00
10ul吸头，透明，袋装，可灭菌 1000支/袋，50袋/箱
10ul吸头，透明，袋装，可灭菌...
85.80

浏览了该商品的用户还浏览了

QIAfilter Plasmid Maxi Kit (10) -10
QIAfilter Plasmid Maxi Kit (...
3000.00
QIAamp DNA Blood Midi Kit (20) 20次
QIAamp DNA Blood Midi Kit (2...
2680.00
QIAamp UCP Pathogen Mini Kit (50)
QIAamp UCP Pathogen Mini Kit...
4112.00
Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M WB, ICC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 06-118
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-SHP-2/SHPTP-2 Antibody
Alternate Names
  • Tyrosine-protein phosphatase non-receptor type 11
  • SHP-2/SHPTP-2
  • Protein-tyrosine phosphatase SYP
  • SH-PTP2
  • SHP-2
  • Shp2
Background Information Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48; UniProt P35235; also known as Protein-tyrosine phosphatase SYP; SH-PTP2, SH2 domain-containing protein tyrosine phosphatase-2, SHP-2, Shp2) is encoded by the Ptpn11 (also known as Syp) gene (Gene ID 19247) in murine species. SHP-2/SHPTP-2 is a non-receptor protein tyrosine phosphatase involved in a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. SHP-2/SHPTP-2 contains two tandem Src homology-2 (SH2) domains that mediate substrates interaction, followed by a protein tyrosine phosphatase PTP domain. Peptide library-based study reveals similar substrate specificities of SHP-2 and the related SHP-1. Both enzymes exhibit preference for acidic and hydrophobic residues flanking the N- and C-terminal sides of target tyrosine residue. Mutations in PTPN11 gene are known to cause Noonan syndrome and acute myeloid leukemia in human.
References
Product Information
Format Affinity Purified
Control
  • Positive Control Included: Non-Stim A431 Cell Lysate (12-301)
Presentation Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Detect SHP-2/SHPTP-2 using this Anti-SHP-2/SHPTP-2 Antibody validated for use in IC & WB.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application Notes Immunocytochemistry Analysis: 4.0 µg/mL from a representative lot detected SHP-2/SHPTP-2 in HeLa, A431, HUVEC, and NIH/3T3 cells.
Biological Information
Immunogen GST-fusion protein containing residues 2-216 of mouse SHP-2/SHPTP-2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes SHP-2/SHPTP-2.
Species Reactivity
  • Human
  • Mouse
Species Reactivity Note Human, Mouse. Predicted to react with Rat based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Gene Symbol
  • PTPN11
  • PTP-2C
  • SH-PTP2
  • SHP-2
  • PTP2C
  • BPTP3
  • SHPTP2
  • SHP2
  • SH-PTP3
  • MGC14433
  • Shp2
  • PTP-1D
  • CFC
  • NS1
Purification Method Protein A Purfied
UniProt Number
Molecular Weight 64 kDa, apparent size increases to approximately 70 kDa upon tyrosine phosphorylation.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected SHP-2/SHPTP-2 in 10 µg of HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 200 μg
Transport Information
Supplemental Information
Specifications

温馨提示:因厂家更改产品包装、产地或者更换随机附件等没有任何提前通知，且每位咨询者购买情况、提问时间等不同，为此以下回复仅对提问者3天内有效，其他网友仅供参考！若由此给您带来不便请多多谅解，谢谢！

我要咨询

咨询内容：
购物指南 免费注册 批量采购 购物流程 购物保障
配送方式 上门自提 第三方配送 炼石配送
支付方式 货到付款 账期付款
售后服务 售后政策 退款说明 售后流程 免责条款

服务热线

0771-3293894

关于我们|帮助中心|诚聘英才|炼石云实验室|联系我们|友情链接

Copyright 2014-2025 炼石云商网络科技（海南）有限公司版权所有 琼ICP备2023006525号-3