0
| Replacement Information |
|---|
| Empirical Formula | CAS # |
|---|---|
| C₁₉H₂₂O₈ | 76958-67-3 |
| Description | |
|---|---|
| Overview | A cell-permeable cis-enone resorlic acid lactone (RAL) and (5Z)-7-Oxozeaenol (Cat. No. 499610) analog that inhibits several kinases via an initial affinity binding to the ATP pocket, followed by a covalent adduct formation with a conserved ATP site cysteine residue of the targeted enzymes, including, but not limited to, Flt1/VEGFR-1, Flt3, cKit(D816V), MAPK1, MAPK2, MEK1, MKK6, PKCμ, PKD2, PRAK, and Tak1 (≥90% inhibition at 2 µM). Hypothemycin is also reported to inhibit two non-RAL targets (99% and 82% inhibition of TrkA and TrkB, respectively, at 2 µM), while one of the 46 putative cis-enone RALs targets, namely GSK-3α, is shown not to be affected. Hypothemycin inhibits multiple kinases involved in MAP kinase pathways and is therefore particularly effective in inhibiting BRAF(V600E)-dependent tumor growth. (5Z)-Zeaenol (Cat. No. 499609) may serve as a negative control. |
| Catalogue Number | 401011 |
| Brand Family | Calbiochem® |
| Synonyms | NSC 354462 |
| References | |
|---|---|
| References | Schirmer, A., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 4234. Solit, D.B., et al. 2006. Nature 439, 358. Tanaka, H., et al. 1999. Jpn. J. Cancer Res. 90, 1139. |
| Product Information | |
|---|---|
| CAS number | 76958-67-3 |
| Form | Lyophilized solid |
| Hill Formula | C₁₉H₂₂O₈ |
| Chemical formula | C₁₉H₂₂O₈ |
| Structure formula Image | |
| Applications |
|---|
| Biological Information | |
|---|---|
| Purity | ≥97% by HPLC |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
温馨提示:因厂家更改产品包装、产地或者更换随机附件等没有任何提前通知，且每位咨询者购买情况、提问时间等不同，为此以下回复仅对提问者3天内有效，其他网友仅供参考！若由此给您带来不便请多多谅解，谢谢！
服务热线
0771-3293894
新浪微博
腾讯微博
QQ空间
客服
