Water-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A.
Catalogue Number
459620
Brand Family
Calbiochem®
References
References
Gjertsen, B.T., et al. 1994. J. Cell Sci.107, 3363. Kiguchi, K., et al. 1994. Cell Growth Differentiation5, 995. Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun.197, 916. Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun.189, 950. Kreienbuhl, P., et al. 1992. Blood80, 2911. Normura, M., et al. 1992. Biochemistry31, 11915. Song, Q., et al. 1992. J. Cell Physiol.153, 550. Tada, Y., et al. 1992. Immunopharmacol.24, 17. Cohen, P., et al. 1990. Trends Biochem. Sci.15, 98. Cohen, P. 1989. Annu. Rev. Biochem.58, 453. Cohen, P., and Cohen, P.T.W. 1989. J. Biol. Chem.254 21435. Haystead, T.A. et al. 1989. Nature337, 78.
Product Information
ATP Competitive
N
Form
White solid - colorless film
Hill Formula
C₄₄H₆₇O₁₃ · Na
Chemical formula
C₄₄H₆₇O₁₃ · Na
Reversible
N
Structure formula Image
Applications
Application
Okadaic Acid, Sodium Salt, is a water-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A.
Biological Information
Primary Target
PP1, PP2
Primary Target IC<sub>50</sub>
10-15 nM, 0.1 nM against protein phosphatase 1, protein phosphatase 2A, respectively
Purity
≥98% by TLC
Physicochemical Information
Cell permeable
N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R Phrase
R: 23/24/25-38
Toxic by inhalation, in contact with skin and if swallowed. Irritating to skin.
S Phrase
S: 22-26-36/37/39-45
Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
-20°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
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