A cell-permeable polyketide that displays potent antitumor properties in eukaryotes. Originally identified as a metabolite from the myxobacterium Sorangium cellulosum for its antibiotic activities against yeasts and filamentous fungi, ratjadones inhibit nuclear export of LR-NES (leucine rich-nuclear export signal)-containing proteins by covalently binding to CRM1. Inhibits proliferation (IC50 ≤ 1 ng/ml) and induces cell cycle arrest at G1 phase.
Catalogue Number
553590
Brand Family
Calbiochem®
Synonyms
Ratjadon, Chromosome Region Maintenance 1 Protein Inhibitor II, CRM1 Inhibitor II, Exportin 1 Inhibitor II, XPO1 Inhibitor II
References
References
Köster, M., et al. 2003. Exp. Cell Res.286, 321. Kalesse, M., et al. 2001. Chem biochem2, 709. Gerth, K., et al. 1995. J. Antibiot.48, 973.
Product Information
CAS number
163564-92-9
ATP Competitive
N
Form
Liquid
Formulation
A 5 µg/ml solution (2 µg in 400 µl) in methanol.
Hill Formula
C₂₈H₄₀O₅
Chemical formula
C₂₈H₄₀O₅
Reversible
N
Structure formula Image
Applications
Biological Information
Primary Target
nuclear export of LR-NES
Primary Target IC<sub>50</sub>
≤ 1 ng/ml for inhibiting proliferation and inducing cell cycle arrest at G1 phase
Purity
≥95% by HPLC
Physicochemical Information
Cell permeable
Y
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code
Dry Ice Only
Toxicity
Flammable
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
≤ -70°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-70°C).
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