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| Replacement Information |
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| Empirical Formula |
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| C₄₄H₆₃Nl₃O₄ |
| Description | |
|---|---|
| Overview | A cell-permeable potent analog of Cyclopamine (Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both ShhNp-induced pathway activity and SmoA1-induced reporter activity. Reported to cause regression of murine tumor allografts in vivo and induce rapid cell death in human medulloblastoma. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. The solid form of this compound (Cat. No. 239804) is also available. |
| Catalogue Number | 239807 |
| Brand Family | Calbiochem® |
| Synonyms | 3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine |
| Product Information | |
|---|---|
| Form | Liquid |
| Formulation | A 1 mM (50 µg/72 µL) solution of Cyclopamine-KAAD (Cat. No. 239804) in DMSO. |
| Hill Formula | C₄₄H₆₃Nl₃O₄ |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Biological Information | |
|---|---|
| Primary Target | SmoA1 |
| Purity | ≥70% by HPLC (sum of two isomers) |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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