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Radicicol, Diheterospora chlamydosporia

市场价：: 0.00

促销价：: ¥0.00

货号：553400-500UG

品牌：Millipore 密理博

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₁₈H₁₇ClO₆	12772-57-5

Description
Overview	A cell-permeable, ATP-site binding, and irreversible antifungal macrocyclic lactone antibiotic that acts as a protein tyrosine kinase inhibitor. Inhibits p60^v-src kinase activity (IC₅₀ = 0.27 nM). Inhibits the expression of COX-2 (IC₅₀ = 27 nM) without affecting COX-1 expression in LPS-stimulated macrophages. Disrupts K-Ras-activated signaling pathways by selectively depleting Raf kinase. Inhibits tyrosine phosphorylation of p53/56^lyn in LPS-stimulated macrophages. Suppresses NIH/3T3 cell transformation by diverse oncogenes such as src, ras, and mos in part by blocking the key signal transduction intermediates such as MAP kinase and GAP-associated p62. Also exhibits anti-angiogenic activity in vivo. Inhibits Wnt-5A expression in dermal papilla cells (IC₅₀ = 190 nM).
Catalogue Number	553400
Brand Family	Calbiochem®

References
References	Shinonaga, H., et al. 2009. Bioorg. Med. Chem. 17, In press. Soga, S., et al. 1998. J. Biol. Chem. 273, 822. Chanmugam, P., et al. 1995. J. Biol. Chem. 270, 5418. Shimada, Y., et al. 1995. J. Antibiot. 48, 824. Zhao, J.F., et al. 1995. Oncogene 11, 161. Oikawa, T., et al. 1993. Eur. J. Pharmacol. 241, 221. Kwon, H.J., et al. 1992. Cancer Res. 52, 6926.

Product Information
CAS number	12772-57-5
Form	White solid
Hill Formula	C₁₈H₁₇ClO₆
Chemical formula	C₁₈H₁₇ClO₆
Structure formula Image

Applications

Biological Information
Primary Target	p60^v-src kinase activity
Primary Target IC<sub>50</sub>	0.27 nM
Secondary target	COX-2 (IC₅₀ = 27 nM)
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	RR1105000

Safety Information
R Phrase	R: 20/21/22-36/37/38 Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

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