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| Replacement Information |
|---|
| Empirical Formula |
|---|
| C₄₄H₆₃N₃O₄ |
| Description | |
|---|---|
| Overview | A potent, cell-permeable analog of Cyclopamine (Cat. No. 239803) that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. Also available as a 1 mM solution in DMSO (Cat. No. 239807). |
| Catalogue Number | 239804 |
| Brand Family | Calbiochem® |
| Synonyms | 3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine, KAAD-Cyclopamine, Shh Signaling Antagonist II |
| Product Information | |
|---|---|
| ATP Competitive | N |
| Form | Pale yellow solid |
| Hill Formula | C₄₄H₆₃N₃O₄ |
| Chemical formula | C₄₄H₆₃N₃O₄ |
| Reversible | N |
| Structure formula Image | |
| Applications |
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| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information | |
|---|---|
| R Phrase | R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. |
| S Phrase | S: 22-36/37 Do not breathe dust. Wear suitable protective clothing and gloves. |
| Product Usage Statements |
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| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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