Replacement Information |
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Empirical Formula |
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C₄₄H₆₃N₃O₄ |
Description | |
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Overview | A potent, cell-permeable analog of Cyclopamine (Cat. No. 239803) that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. Also available as a 1 mM solution in DMSO (Cat. No. 239807). |
Catalogue Number | 239804 |
Brand Family | Calbiochem® |
Synonyms | 3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine, KAAD-Cyclopamine, Shh Signaling Antagonist II |
Product Information | |
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ATP Competitive | N |
Form | Pale yellow solid |
Hill Formula | C₄₄H₆₃N₃O₄ |
Chemical formula | C₄₄H₆₃N₃O₄ |
Reversible | N |
Structure formula Image |
Applications |
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Physicochemical Information | |
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Cell permeable | Y |
Dimensions |
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Materials Information |
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Toxicological Information |
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Safety Information according to GHS |
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Safety Information | |
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R Phrase | R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. |
S Phrase | S: 22-36/37 Do not breathe dust. Wear suitable protective clothing and gloves. |
Product Usage Statements |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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Specifications |
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