Rapamycin

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货号：553210-100UG

品牌：Millipore 密理博

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₅₁H₇₉NO₁₃	53123-88-9

Description
Overview	Anti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC₅₀ = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser⁴⁷³ appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110^Rb phosphorylation, p34^cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G₁ phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G₁ phase. A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553211) in DMSO and a 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553212) in EtOH is also available.
Catalogue Number	553210
Brand Family	Calbiochem®
Synonyms	mTOR Inhibitor I

References
References	Chen, T., et al. 2011. Aging Cell. 10, 908. Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794. Braun, W., et al. 1995. FASEB J. 9, 63. Nielsen, F.C., et al. 1995. Nature 377, 358. Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493. Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350. Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734. Terada, N., et al. 1993. J. Biol. Chem. 268, 12062. Kuo, J., et al. 1992. Nature 358, 70. Price, D.J., et al. 1992. Science 257, 973. Heitman, J., et al. 1991. Science 253, 905. Kay, J.E., et al. 1991. Immunology 72, 544. Schreiber, S.L. 1991. Science 251, 283. Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231. Dumont, F.J., et al. 1990. J. Immunol. 144, 251.

References

Chen, T., et al. 2011. Aging Cell. 10, 908.
Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
Braun, W., et al. 1995. FASEB J. 9, 63.
Nielsen, F.C., et al. 1995. Nature 377, 358.
Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
Kuo, J., et al. 1992. Nature 358, 70.
Price, D.J., et al. 1992. Science 257, 973.
Heitman, J., et al. 1991. Science 253, 905.
Kay, J.E., et al. 1991. Immunology 72, 544.
Schreiber, S.L. 1991. Science 251, 283.
Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
Dumont, F.J., et al. 1990. J. Immunol. 144, 251.

Product Information
CAS number	53123-88-9
ATP Competitive	N
Form	Clear film
Hill Formula	C₅₁H₇₉NO₁₃
Chemical formula	C₅₁H₇₉NO₁₃
Reversible	N
Structure formula Image

Applications

Biological Information
Primary Target	Mammalian target of rapamycin (mTOR)
Primary Target IC<sub>50</sub>	50 pM against p70 S6 kinase
Purity	≥99% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	VE6250000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.