0
| Replacement Information |
|---|
| CAS # |
|---|
| 95076-93-0 |
| Description | |
|---|---|
| Overview | Recombiant, human cyclophilin A expressed in E. coli. An ubiquitous enzyme that catalyzes the cis-trans-isomerization of X-Pro peptide bonds. Binds to proteins and acts as a chaperone in protein folding. Incorporates into HIV-1 virons and is believed to be essential for viral infectivity. Cyclophilin binds to the immunosuppressant Cyclosporin A (Cat. No. 239835). This complex then binds calcineurin (PP2B) and inhibits its phosphatase activity. |
| Catalogue Number | 239777 |
| Brand Family | Calbiochem® |
| Synonyms | Peptidylproline cis-trans-Isomerase |
| Product Information | |
|---|---|
| CAS number | 95076-93-0 |
| ATP Competitive | N |
| EC number | 5.2.1.8 |
| Form | Liquid |
| Formulation | In 20 mM Tris-HCl, pH 7.8. |
| Reversible | N |
| Applications |
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| Physicochemical Information | |
|---|---|
| Cell permeable | N |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information | |
|---|---|
| S Phrase | S: 24/25-36 Avoid contact with skin and eyes. Wear suitable protective clothing. |
| Product Usage Statements |
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| Packaging Information |
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| Transport Information |
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| Supplemental Information |
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| Specifications |
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