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Empirical Formula | CAS # |
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C₃₁H₃₈N₄O₅S | 797035-11-1 |
Description | |
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Overview | A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). The solid form of this compound (Cat. No. 565788) is also available. |
Catalogue Number | 565794 |
Brand Family | Calbiochem® |
Synonyms | N-(1S, 2R)-1-Benzyl-3-(cyclopropylamino)-2-hydroxypropyl)-5-(methyl(methylsulfonyl)amino-Nʹ-((1R)-1-phenylethyl)isophthalamide |
References | |
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References | Stachel, S.J., et al. 2004. J. Med. Chem. 47, 6447. |
Product Information | |
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CAS number | 797035-11-1 |
Form | Liquid |
Formulation | A 10 mM (500 µg/86.4 µL) solution of β-Secretase Inhibitor IV (Cat. No. 565788) in DMSO. |
Hill Formula | C₃₁H₃₈N₄O₅S |
Hygroscopic | Hygroscopic |
Reversible | Y |
Structure formula Image |
Applications |
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Biological Information | |
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Primary Target | β-Secretase |
Primary Target IC<sub>50</sub> | 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells |
Purity | ≥95% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
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Safety Information according to GHS |
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Product Usage Statements |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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