NEMO-Binding Domain Binding Peptide, Cell-Permeable - 炼石商城

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NEMO-Binding Domain Binding Peptide, Cell-Permeable

市场价：: 0.00

促销价：: ¥0.00

货号：480025-500UG

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula
C₁₇₀H₂₅₉N₄₉O₄₂S

Description
Overview	A cell-permeable Antennapedia-NBD (wild type) fusion peptide that exhibits anti-inflammatory properties. Acts by inhibiting cytokine-induced NF-κB activation and NF-κB-dependent gene expression. Suggested to block the interaction of NEMO with the IKK (IκB)-kinase complex and thereby prevents NF-κB activation. Does not affect the TNF-α-induced phosphorylation of c-Jun and DNA binding of the transcription factor Oct-1.
Catalogue Number	480025
Brand Family	Calbiochem®
Synonyms	DRQIKIWFQNRRMKWKKTALDWSWLQTE, NBD-Binding Peptide, Cell Permeable

References
References	Jimi, E., et al. 2004. Nat. Med., 10, 617. Siegmund, D., et al. 2001. J. Biol. Chem. 276, 43708. May, M.J., et al. 2000. Science 289, 1550. Li, Q., et al. 1999. Science 284, 321.

Product Information
ATP Competitive	N
Form	White lyophilized solid
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₁₇₀H₂₅₉N₄₉O₄₂S
Chemical formula	C₁₇₀H₂₅₉N₄₉O₄₂S
Hygroscopic	Hygroscopic
Reversible	N

Applications
Application	NEMO-Binding Domain Binding Peptide, Cell-Permeable, is an Antennapedia-NBD (wild type) fusion peptide that blocks the interaction of NEMO with the IKK (IκB)-kinase complex.

Biological Information
Primary Target	cytokine-induced NF-κB activation and NF-κB-dependent gene expression
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	H-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Trp-Ser-Trp-Leu-Gln-Thr-Glu-OH

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

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