B-SECRETASE SUBSTRATE VI, FLUOROGENIC - 炼石商城

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B-SECRETASE SUBSTRATE VI, FLUOROGENIC

市场价：: 0.00

促销价：: ¥0.00

货号：565781-500UG

品牌：Millipore 密理博

配送至：

北京朝阳

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数量：

EA (预计3-5工作日到货)

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Replacement Information

Description
Overview	A highly selective, fluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE); (pH ~4.0, k_cat = 0.02 sec^-1; K_m = 9 µM). Derived from the Swedish mutant APP (amyloid precursor protein) β-cleavage site (-NL↓DA-). Useful for high throughput screening of β-secretase inhibitors.
Catalogue Number	565781
Brand Family	Calbiochem®
Synonyms	H-K(DABSYL)-SEVNLDAEFRQ(LY)

References
References	Grüninger-Leitch, F., et al. 2002. J. Biol. Chem. 277, 4687.

Product Information
ATP Competitive	N
Form	Lyophilized solid
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₈₉H₁₂₂N₂₄O₃₁S₃
Chemical formula	C₈₉H₁₂₂N₂₄O₃₁S₃
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image

Applications

Biological Information
Primary Target	Fluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE)
Primary Target IC<sub>50</sub>	kcat = 0.02 sec⁻¹ and Km = 9 µM at pH ~4.0 as fluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE)
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N
Emission max.
Excitation max.
Peptide Sequence	H-Lys(DABSYL)-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Gin-(LY)

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

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